Magnetization transfer using inversion recovery during off-resonance irradiation

Enhanced detection of cortical lesions in multiple sclerosis using magnetization transfer and double inversion recovery

Purpose: Multiple sclerosis (MS) has long been considered a pure white matter (WM) disease. In recent years, greater attention is paid to cortical pathology in MS. However, detection of cortical lesions is complicated by low contrast on MRI between lesions and surrounding tissue, the relatively low image resolution, and the confounding signal from WM and cerebrospinal fluid (CSF). Double invers...

Quantitative magnetization transfer imaging of rodent glioma using selective inversion recovery.

Magnetization transfer (MT) provides an indirect means to detect noninvasively variations in macromolecular contents in biological tissues, but, so far, there have been only a few quantitative MT (qMT) studies reported in cancer, all of which used off-resonance pulsed saturation methods. This article describes the first implementation of a different qMT approach, selective inversion recovery (S...

Quantitative Magnetization Transfer Imaging of Human Brain at 3T using Selective Inversion Recovery

R. D. Dortch, K. Li, A. A. Tamhane, E. B. Welch, D. F. Gochberg, J. C. Gore, and S. A. Smith Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United Sta...

Magnetization transfer weighted double inversion recovery for an improved visualization of neocortical and juxtacortical signal abnormalities

Optimized inversion recovery sequences for quantitative T1 and magnetization transfer imaging.

Inversion recovery sequences that vary the inversion time (t(i)) have been employed to determine T(1) and, more recently, quantitative magnetization transfer parameters. Specifically, in previous work, the inversion recovery pulse sequences varied t(i) only while maintaining a constant delay (t(d)) between repetitions. T(1) values were determined by fitting to a single exponential function, and...